A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase

2023-05-05 09:42:48

Canadian researchers have discovered how a previously overlooked gene is involved in antimicrobial resistance. The gene encodes for an enzyme named EstT and is capable of "turning off" or inactivating macrolides, a class of antibiotic drugs commonly used to treat disease in cattle and other livestock. The finding adds to the considerable database of ARGs, which can be crossmatched to a bacteria's DNA to determine if the bacterium has the potential to be resistant to a particular antimicrobial.